Knowledge/REJURAN vs Profhilo vs Juvelook: How to Choose Among Three Hydrating Repair Treatments
Injectables

REJURAN vs Profhilo vs Juvelook: How to Choose Among Three Hydrating Repair Treatments

REJURAN uses PN to repair the skin’s underlying environment; Profhilo uses high-concentration hyaluronic acid to improve hydration; Juvelook combines PDLLA with hyaluronic acid to support collagen production.

REJURAN vs Profhilo vs Juvelook: How to Choose Among Three Hydrating Repair Treatments

The three treatments each have a different emphasis: REJURAN uses PN to repair the skin’s underlying environment; Profhilo uses high-concentration hyaluronic acid to improve hydration and elasticity; Juvelook combines PDLLA with hyaluronic acid to support collagen production. Choose REJURAN if you want to improve skin quality, Profhilo if you want more hydration, and Juvelook if you want pore refinement together with collagen repair. None is absolutely superior; the key is whether the skin’s needs match the treatment mechanism.

Comparison of composition and mechanism

ItemREJURANProfhiloJuvelook
Core ingredientPN (polynucleotide), extracted from salmon DNA64 mg high-concentration hyaluronic acidPDLLA microparticles + non-cross-linked hyaluronic acid
Direction of actionDeep-skin repair, cell regenerationDiffusive hydration, structural remodellingCollagen production + immediate hydration
Suitable concernsRough texture, dullness, fine linesDryness, reduced elasticityEnlarged pores, early fine lines

Pace of results

  • REJURAN: usually noticeable in 2–4 weeks; collagen production and fine-line improvement at 1–3 months
  • Profhilo: a hydrated feel comes relatively quickly; structural reorganisation takes several weeks
  • Juvelook: HA hydration can be seen immediately; the collagen response takes weeks to months

All three produce progressive results. Immediate dramatic change should not be expected, and none of the results is permanent; regular maintenance is needed to sustain them.

How to choose

  • Rough texture, dullness, lack of radiance → REJURAN
  • Dryness, dehydration, reduced elasticity → Profhilo
  • Enlarged pores, early fine lines → Juvelook
  • Want both hydration and collagen production → Juvelook (dual mechanism)

Side effects and risks

Common post-treatment reactions for all three include needle marks, mild redness and swelling, tenderness and tiny raised spots, usually temporary. REJURAN also carries a fish-allergy risk (PN is extracted from salmon DNA); Profhilo and Juvelook also carry hyaluronic acid–related allergy risk.

Book ConsultationBack to knowledge