REJURAN uses PN to repair the skin’s underlying environment; Profhilo uses high-concentration hyaluronic acid to improve hydration; Juvelook combines PDLLA with hyaluronic acid to support collagen production.

The three treatments each have a different emphasis: REJURAN uses PN to repair the skin’s underlying environment; Profhilo uses high-concentration hyaluronic acid to improve hydration and elasticity; Juvelook combines PDLLA with hyaluronic acid to support collagen production. Choose REJURAN if you want to improve skin quality, Profhilo if you want more hydration, and Juvelook if you want pore refinement together with collagen repair. None is absolutely superior; the key is whether the skin’s needs match the treatment mechanism.
| Item | REJURAN | Profhilo | Juvelook |
|---|---|---|---|
| Core ingredient | PN (polynucleotide), extracted from salmon DNA | 64 mg high-concentration hyaluronic acid | PDLLA microparticles + non-cross-linked hyaluronic acid |
| Direction of action | Deep-skin repair, cell regeneration | Diffusive hydration, structural remodelling | Collagen production + immediate hydration |
| Suitable concerns | Rough texture, dullness, fine lines | Dryness, reduced elasticity | Enlarged pores, early fine lines |
All three produce progressive results. Immediate dramatic change should not be expected, and none of the results is permanent; regular maintenance is needed to sustain them.
Common post-treatment reactions for all three include needle marks, mild redness and swelling, tenderness and tiny raised spots, usually temporary. REJURAN also carries a fish-allergy risk (PN is extracted from salmon DNA); Profhilo and Juvelook also carry hyaluronic acid–related allergy risk.