Collagen stimulators use specific ingredients (PCL, CaHA, PLLA, PDLLA and others) to stimulate the skin to produce new collagen, improving skin quality and increasing firmness. Different brands vary in composition, particle design and application features.
Detailed comparison of major brands
| Product | Main ingredients | Immediate fill | Collagen stimulation | Duration |
|---|
| Ellansé | PCL + CMC | High | High | 1–4 years |
| Radiesse | CaHA + CMC | Highest | High | 12 months+ |
| Juvelook | PDLLA + HA | Low | High | 12–18 months |
| AestheFill | PDLLA + CMC | High | High | 18–24 months |
| Sculptra | PLLA | Low | Highest | 24 months |
| Derma Veil | PLLA | Low | High | 24 months |
| HArmonyCa | CaHA + HA | Highest | High | 18–24 months |
Features of each brand
- Ellansé: CMC gel provides immediate fill; PCL microspheres stimulate Type I collagen regeneration — suitable for large-area filling
- Radiesse: CaHA microspheres build a foundation at the fibroblast layer, combining immediate and lasting fill
- Juvelook: a lighter, softer formula, less likely to form lumps; no massage needed after treatment
- AestheFill: a newer form of poly-D,L-lactic acid, suitable for thinner-skinned areas
- Sculptra: the only PLLA medical aesthetic brand worldwide with US FDA recognition, for progressive, natural regeneration
- HArmonyCa: combines the dual advantages of CaHA and hyaluronic acid, lifting immediately while stimulating the skin’s own collagen
How to choose
- Seeking immediate fill and contouring: Radiesse, HArmonyCa, Ellansé
- Seeking progressive, natural collagen regeneration: Sculptra, Derma Veil, Juvelook
- Improving skin quality, fine lines and pores: Juvelook, Gouri, Derma Veil
- For thinner-skinned areas: AestheFill, Derma Veil
Side effects and precautions
- Common side effects include redness, bruising or mild pain at the injection site, usually settling within a few days
- After injection, it is advisable to avoid vigorous exercise, direct sunlight and hot baths
- Initial results may be seen within a few days after injection; the best results appear gradually over several weeks
